The Nanobioelectronics Laboratory introducing themselves and their research:
Bi-directional communication of information between biological and electronic systems is governed by transfer of electrons. For example, the behavior of physiological systems in the human body is represented by biochemical molecules and ions that are transduced to electronic signals. These biological systems usually composed of various components (DNA, proteins, signal molecules etc.) and assemble into complex structures, both arise difficulties in gathering and analyzing the generated information. Microbiome-on-a-chip and organ-on-a-chip combined with microfluidics may enable suitable platform for data collection based on electrochemical and optical sensing. Here, we present two studies regarding bioelectronic lab-on-a-chip. One study focuses on three-dimensional modified multielectrode array for analysis of biofilm producing bacteria (Oriya Ester Belous). Another study focuses on developing micro-bioelectronic systems that mimics the interkingdom redox relationships of the eukaryotic-mucus-prokaryotic biosystem in the gut (Daniel Kaufman). In the two studies we utilize micro-electronics design and fabrication methods, chemical and electrochemical modification for the electrodes and the integration of biological cultures on micro-electronics.
- Oriya Ester Belous.
- Daniel Kaufman.
Intelligent Multi-electrode arrays for in situ analysis
The goal of the research is to develop the intelligent multi-micro electrode array for in-situ and in vivo analysis of electrochemically active biomarkers. The main aim is (i) to develop the sensor array on rigid substrates (silicon, glass) and then developing the flexible substrate (PET, Kapton, PDMS) based multi micro-electrode array, (ii) Integrate intelligent electrochemical sensor technology in flexible patch-targeted technology (iii) detection and quantification of (i) neurotransmitters such as dopamine, L-DOPA, serotonin, norepinephrine, Levetiracetam etc. (ii) biomarkers present in biofluids such as blood, serum, sweat and urine, (iii) in vivo bio electrochemical sensing of neurotransmitters.
- Dr.Dayananda Desagani
- Dr. Murugaiya Sridar Ilango
- Ahed Shibli
Microsystems for Environmental monitoring
Environmental pollution is creating alterations to our ecosystem and possess a serious threat for living organisms. These unwanted pollutants may be affecting directly or indirectly the atmosphere to create a long term negative impact. Per/polyfluoroalkyl (PFAS) is evolving and forever chemical contaminant present in the environment with fluorinated compounds. PFAS is present in nonstick cookware products, fast food wrappers, aqueous film forming foams and stain resistant fabrics. PFAS is one of the intractable materials impacting the environment. PFAS can affect human health in several ways such as cancer and abnormalities. It is important to detect PFAS in the environmental samples, the present detection techniques are expensive, time taking and complex systems. Electrochemical sensors can provide solutions for these challenges. It will have provide in situ detection of PFAS. We are studying on the detection of PFAS and controlling the filtration of PFAS. In this study we are fabricating and optimizing an electronic tongue with multi-array electrodes and different modifications (Meghna). The study also focusses in the development of a filtration membrane with controlled pore size to reject PFAS. The combination of membrane and electrochemical sensor will help to detect and remove PFAS from the water samples (Murugaiya Sirdar). The multi-array micro electrodes are designed and fabricated (Alex), further modified with different materials and integrated in microelectronics.
Fig 1: Schematic representation of the detection of PFAS with ELPs modified electrode
Students and Postdocs:
- Dr. Murugaiya Sridar Ilango
- Meghna Khadka.