Ben-Yoav Research Group - Nanobioelectronics
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Bio-Microelectromechanical Systems (Bio-MEMS)


Microfluidic lab-on-a-chip for DNA hybridization analysis

Lab-on-a-chip devices for electrochemical analysis of DNA hybridization events offer a technology for real-time and label-free assessment of biomarkers at the point-of-care. Here, we present a microfluidic lab-on-a-chip, with arrayed electrochemical sensors for the analysis of DNA hybridization events. A new dual layer microfluidic valved manipulation system is integrated providing controlled and automated capabilities for high throughput analysis. This feature improves the repeatability, accuracy, and overall sensing performance.
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Selected Accomplishments:

  • Discovered a new diffusion-based biosensing mechanism of DNA hybridization events
  • Developed an automated arrayed multi-layer microfluidic device for programmable detection of ssDNA targets

Students and Postdocs:

  • Dr. Peter Dykstra

Collaborators:

Professor William E. Bentley (University of Maryland College Park)
Professor Reza Ghodssi (University of Maryland College Park)

Support:


  • The Robert W. Deutsch Foundation
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Selected Publications:

  • Ben-Yoav, H., Dykstra, P. H., Bentley, W. E., and Ghodssi, R. A controlled microfluidic electrochemical lab-on-a-chip for label-free diffusion-restricted DNA hybridization analysis. Biosensors and Bioelectronics 64, pp. 579-585, 2015. Click to download article
  • Ben-Yoav, H., Dykstra, P. H., Gordonov, T., Bentley, W. E., and Ghodssi, R. A microfluidic-based electrochemical biochip for label-free DNA hybridization analysis. Journal of Visualized Experiments 91, e51797, 2014. 
  • Ben-Yoav, H., Dykstra, P. H., Bentley, W. E., and Ghodssi, R. A microfluidic-based electrochemical biochip for label-free diffusion-restricted DNA hybridization analysis. Biosensors and Bioelectronics 38 (1), pp. 114-120, 2012. Click to download paper
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  • Home
  • Available Positions
  • Members
  • Research Projects
    • Analytical Micro-Systems for Personalized Health Monitoring
    • Bio-Microelectromechanical Systems (Bio-MEMS)
    • Nanoelectronic Systems and Biomaterials
    • Previous Projects
  • Teaching
  • Facilities
  • Resources
    • Administrative
    • Calendar and Equipment Scheduler
    • Knowledge Base
    • Vendors