Bio-Microelectromechanical Systems (Bio-MEMS)
Microfluidic lab-on-a-chip for DNA hybridization analysis
Lab-on-a-chip devices for electrochemical analysis of DNA hybridization events offer a technology for real-time and label-free assessment of biomarkers at the point-of-care. Here, we present a microfluidic lab-on-a-chip, with arrayed electrochemical sensors for the analysis of DNA hybridization events. A new dual layer microfluidic valved manipulation system is integrated providing controlled and automated capabilities for high throughput analysis. This feature improves the repeatability, accuracy, and overall sensing performance.
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Selected Accomplishments:
- Discovered a new diffusion-based biosensing mechanism of DNA hybridization events
- Developed an automated arrayed multi-layer microfluidic device for programmable detection of ssDNA targets
Students and Postdocs:
- Dr. Peter Dykstra
Collaborators:
Professor William E. Bentley (University of Maryland College Park)
Professor Reza Ghodssi (University of Maryland College Park)
Professor Reza Ghodssi (University of Maryland College Park)
Support:
Selected Publications:
- Ben-Yoav, H., Dykstra, P. H., Bentley, W. E., and Ghodssi, R. A controlled microfluidic electrochemical lab-on-a-chip for label-free diffusion-restricted DNA hybridization analysis. Biosensors and Bioelectronics 64, pp. 579-585, 2015. Click to download article
- Ben-Yoav, H., Dykstra, P. H., Gordonov, T., Bentley, W. E., and Ghodssi, R. A microfluidic-based electrochemical biochip for label-free DNA hybridization analysis. Journal of Visualized Experiments 91, e51797, 2014.
- Ben-Yoav, H., Dykstra, P. H., Bentley, W. E., and Ghodssi, R. A microfluidic-based electrochemical biochip for label-free diffusion-restricted DNA hybridization analysis. Biosensors and Bioelectronics 38 (1), pp. 114-120, 2012. Click to download paper
